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PLoS ONE 10(6): e0129991

IGF-1 LR3 promotes tissue repair and muscle hypertrophy by directly acting on muscle cells, while MOTS-c enhances glucose utilization and mitochondrial function

Amino acid profiling siblings discordant for konzo identifies deficiencies in key sulfur amino acids and suggests mitochondrial distress To determine if siblings discordant for konzo had major differences in amino acid profiles which may contribute to changes in GPx3 abundance, we used an HPLC-based approach to quantify plasma amino acids in samples from study participants