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Female Wistar rats (8-10 weeks old) may receive subcutaneous injections of 2 mg/kg (24) or 4 mg/kg (25) estradiol valerate for 60 consecutive days to establish a PCOS model

Hirabayashi Y, Kwon S-K, Paek H, Pernice WM, Paul MA, Lee J, et al

Activated microglia release even more neurotoxic mediators, perpetuating a state of chronic neuroinflammation

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That is why our formula also includes GABA (gamma-aminobutyric acid), an essential neurotransmitter that helps regulate brain activity