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It functions as a reversal agent by competitively inhibiting P-glycoprotein (P-gp) efflux pumps and transcriptionally suppressing MDR1 expression via the AP-1 and NF-B axes [51,52,53]

Melatonin, as an internal temporal cue contributing to circadian organization and best studied in the context of circadian misalignment, is also implicated in neuroplasticity

Patients with untreated Lyme disease have a significant chance of developing persistent signs and symptoms, primarily in the form of arthritis and less commonly, neurologic disease (173)