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Elevated levels of extracellular heat-shock protein 72 (ehsp72) are positively correlated with insulin resistance in vivo and cause pancreatic beta-cell dysfunction and death in vitro

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Surface modification Surface modification of nanoparticles, such as encapsulating materials such as polyethylene glycol (PEG) and chitosan, to enhance their adhesion to gastrointestinal mucosa and prolong the residence time of drugs in the gastrointestinal tract

The p53(3KR) mutant, lacking acetylation due to lysine-to-arginine substitutions at three residues, decreases expression of SLC7A11 without affecting other p53 targets such as CDKN1A/p21 (involved in cell cycle progression) or BAX (involved in apoptosis)

Personalized Treatment plan Dosage adjustment: Adjust the injection dosage based on the patient's weight and fat distribution