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Moreover, it is likely that other antioxidant mechanisms might be at play to control ROS levels in the cell, such as the nuclear factor E2-related factor 2 ( NRF2 ), which is a transcription factor that binds to the antioxidant response element (ARE) under oxidative stress 40

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Each sample pool, herein called libraries, was subsequently fractionated into 24 fractions by highpH reversedphase chromatography using the Spider fractionator as described previously (Kulak et al , 2017)

HYPOPITUITARISM and HYPOTHYROIDISM Secondary hypothyroidism should be considered in patients presenting with low FT4 and normal (or only slightly raised) TSH