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Reconstituted Liquid State: Once mixed with a laboratory solvent like bacteriostatic water, the blend is highly sensitive to temperature and structural shearing

Jakaria et al

Eter-connected thalidomide-based PROTACs The synthesis of 4-hydroxythalidomide (57) can be obtained by condensation between 3-hydroxyphthalo anhydride (56) and the glutarimide ring, under different conditions and reagents (Scheme 9) 110,111,112