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Acknowledgments We thank Douglas Kintner at the Waisman Center for his assistance in manuscript editing

This docking exercise guided us to synthesise compounds 3744

Miniosmotic pump implantation and ICV GDF11 infusion in mice Twenty-four hours before implantation, programmable and refillable miniosmotic pumps (iPrecio, SMP-300) were filled with saline, under sterile conditions, and programmed to deliver the infusion at a constant rate of 1 l h 1

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