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Oxidative stress, a state where the oxidative and antioxidant systems are out of balance, leading to potential cellular damage

Intracellular AGE accumulation can stimulate aberrant protein glycation, abnormal protein folding, and the aggregation of irregular or oligomeric proteins, as well as elevated oxidative stress and inflammation and upregulated apoptotic signaling pathways

Fricker M, Tolkovsky AM, Borutaite V et al (2018) Neuronal Cell Death

X-linked gene with mosaic expression in females Conversion of 6-phosphogluconolactone to 6-phosphogluconate by lactonase : irreversible Conversion of 6-phosphogluconate to ribulose-5-phosphate by 6-phosphogluconate dehydrogenase : irreversible NADPH produced, CO 2 released Reactions of the Non-Oxidative Phase: Interconversion of ribulose-5-phosphate and xylulose-5-phosphate by phosphopentose epimerase (ribulose-5-phosphate epimerase) : reversible Interconversion of ribulose-5-phosphate and ribose-5-phosphate by phosphopentose isomerase (ribose-5-phosphate ketoisomerase) : reversible Ribose is a major component of nucleic acids