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[6] Protein aggregation represents a major event of physical instability of proteins and occurs due to the inherent tendency to minimize the thermodynamically unfavorable interaction between the solvent and hydrophobic protein residues

But previous studies have hypothesized oxidative stress as a common biochemical signature 26 and even shown some evidence in circulating serum redox proteins (e.g., myeloperoxidase) 59, 75 among LC patients