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J., Luo, Y., Michelsen, A., Pendall, E., Reich, P

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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide

doi: 10.3109/10715762.2013.778403 70 WangJFieldsJZhaoCLangerJThimmulappaRKKenslerTWet al

Notably, IL-6 not only modulates hepcidin to affect the release of stored iron from ATMs and intestinal absorption, but also reduces transferrin expression and aggravates iron accumulation by promoting hepcidin production