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Emerging strategies, including nanotechnology-based delivery systems and combination therapies, aim to overcome these barriers, enhancing the efficacy and applicability of antioxidants in combating neurodegenerative diseases

Recent studies have indicated that naturally occurring plants compounds possess antioxidant properties

These cells are classically divided between those considered protoplasmatic and those considered fibrous, by their grey and white matter origins, respectively

During both the OE-1 and OE-2 tests, approximately 4% and 1% of activated cells were defined as positively or negatively correlated neurons, regardless of genotype (Fig 5C), indicating that Tbr1 +/ mice do not differ from WT mice in terms of numbers of activated neurons during OE