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Country-specific unit costs were used with cost estimates reported on a per capita basis, after adjustment for price differentials

Opioid receptors cannot tell the difference between opioids that are made naturally by the body, such as endorphins, opioids that are produced by plants, such as heroin from the opium poppy or mitragynine from kratom (opiates), or opioids that are created in a laboratory, such as fentanyl and loperamide (synthetic opioids)

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Serious (rare): Allergic reactions, rapid heartbeat, difficulty breathing

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