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The adenosine moiety of ATP has a high structural homology to the indole moiety of melatonin (Figure 2)

Analysis of genetic polymorphism in NQO1 , GST-M1 , GST-T1 and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemia Clin Cancer Res 2000 6 : 40914095 Ohno R, Kobayashi T, Tanimoto M, Hiraoka A, Imai K, Asou N, Tomonaga M, Tsubaki K, Takahashi I, Kodera Y, Yoshida M, Murakami H, Naoe T, Shimayama M, Tsukada T, Takeo T, Teshima H, Onozawa Y, Fujimoto K, Kuriyama K, Horiuchi A, Kimura I, Minami S, Miura Y, Kageyama H, Tahara T, Masaoka T, Shirakawa S, Saito H

Thus, therapeutic modulation of mitophagy requires fine-tuning rather than blanket activation or inhibition

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Dutta, S