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Vitamin D in human reproduction

4.2.3 Targeting lactylation modification sites In contrast to the aforementioned strategies that indirectly modulate lactylation levels by regulating enzyme activity, a more precise interventional approach involves directly targeting the lactylation modification sites themselves, either by recognizing or blocking pathogenic modification events with specific antibodies, including pan-specific antibodies (anti-pan-Kla) that can identify lactic acid lysine residues in all proteins, and multi-site specific antibodies, such as anti-H3K18la, anti-H3K14la and anti-XRCC1 K247la

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Specifically, the active constituents were found to inhibit cancer cell growth and metastasis by affecting mitochondrial function, regulating the expression of apoptosis-related proteins, and interfering with cell signaling pathways such as PI3K/AKT, AMPK, MAPK, and EGFR

While women are often introduced to preventive healthcare through reproductive health visits, pregnancy care, and routine screening programs, men frequently lack comparable touchpoints