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In that rulemaking (85 FR 58891), we adopted a policy that required hospitals to report on the Medicare cost report the median payer-specific negotiated charge that the hospital had negotiated with all of its Medicare Advantage Organizations (MAOs), by MS-DRG, effective for cost reporting periods ending on or after January 1, 2021

This is further metabolized by microsomal epoxide hydrolase

Mller P, Fischer H, Sorger D

[] MiD51 requires adenosine diphosphate (ADP) binding to stimulate DRP1 oligomerization and GTPase activity