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SIRT5-mediated GLS and GDH desuccinylation attenuates the autophagy of bovine mammary epithelial cells induced by ammonia

As glutathione levels fall due to apoptosis, the oxidized form of gliotoxin effluxes from the cell where the cytocidal effects of gliotoxin are perpetuated in a pseudocatalytic manner

PERK phosphorylates eIF2 to rapidly inhibit general protein translation to reduce the stress load and activate ATF4, which promotes chaperone production and stress response genes [2123]