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516 Hah et al

[2] The anti-inflammatory dimension dampening of pro-inflammatory cytokine signaling and support of antioxidant defenses is proposed as the mechanism that keeps the repair environment from tipping into chronic inflammation and fibrosis

Collectively, these observations indicate that, despite their similar BMI, obese subjects with low IGF-1 levels are markedly more predisposed to have multiple metabolic abnormalities, such as increased adiposity, inflammation, dyslipidemia and hyperuricemia than subjects in the standard IGF-1 range