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Furthermore, postprandial plasma SFA and MUFA were higher, and total FA consisted of a larger percentage of SFA, and a lower percentage of PUFA postprandially in liver compared to muscle IR

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The secreted IGF-1 binds to IGF-1R on matrix keratinocytes, initiating a signaling cascade through two parallel pathways: PI3K/Akt pathway: IGF-1R activation phosphorylates PI3K, which activates Akt (protein kinase B)