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Description

Elevates NAD+ and S-adenosylmethionine (SAM) levels, shifting metabolic flux toward energy expenditure and away from fat storage 1-4

Physiol Rev 94(2):32954

Increased levels of programmed cell death 5 (PDCD5) subsequently ameliorated progressive fibrosis and cardiac dysfunction by inhibiting histone deacetylase 3 (HDAC3), suggesting that PDCD5 serves as an endogenous negative feedback regulator in progressive cardiac fibrosis [109]