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To receive approval, a drug must pass through a series of studies testing its use in humans

Helander IM, Nurmiaho-Lassila EL, Ahvenainen R et al (2001) Chitosan disrupts the barrier properties of the outer membrane of Gram-negative bacteria

184 In a mouse model of male infertility, shilajit improved testicular function, increased sperm and testosterone production, reversed the toxic effect of the heavy metal cadmium on sperm motility and concentration, and induced fertility