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10,23,25 One cross-sectional study involving a cohort of patients with diverse causes of CKD showed that increased HIF pathway activity in the glomerular compartment was more common in patients with nephrosclerosis and was associated with decreased estimated glomerular filtration rate

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Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

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In cancer cells, increased lactate concentrations have been reported to suppress apoptosis through HIF-1-mediated upregulation of anti-apoptotic proteins, including BCL-2 and survivin, while concurrently promoting ferroptosis resistance via SCD1 upregulation (58,141)

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Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options

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Figure 1 A critical element in the pathophysiology of sepsis is endothelial dysfunction, which correlates with disease severity and mortality

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