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An example is B003-2A, a recently developed IGF-1R anti-idiotypic antibody antagonist, which abrogated the IGF-1R-mediated proliferation of ovarian cancer cells in vivo and in vitro and overcame resistance to cisplatin in ovarian cancer cell lines (64, 74)

When the concentration of uric acid in blood and synovial fluid exceeds physiological solubility, SUA transitions into a thermodynamically supersaturated state