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28 It has been reported that transformation of SAM to SAH determined the transsulfuration pathway activity, inducible of which contributed to cellular cysteine pool and promoted cancer cell growth upon cysteine restriction

Research indicates that vodobatinib and IKT-148009, two next-generation c-Abl inhibitors, exhibit superior brain penetration and more potent inhibition of cerebral c-Abl compared to nilotinib, showing considerable promise for PD treatment [160162]