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Indo-1 fluorescence signals were measured 2 h after treatment with PMA (100 nM), A23187 (1.25 M) or PMA in the presence of BAPTA-AM (25 M) ( n = 3) ( e ), and quantification of intracellular Ca 2+ levels in PS-exposed (Annexin V + ) versus non-exposed (Annexin V ) cells at 2 h following PMA stimulation ( n = 3) ( f )

In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes

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Other people may become B12 deficient if they lack certain gut enzymes that allow the body to 'extract' B12 for animal sources

We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo