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Changes in hyaluronan production and metabolism following ischaemic stroke in man

In addition to transcriptional regulation, the expression of GPX4 is also regulated at the protein level [43]

For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress ( in situ GSH in tumor triggered mCMSNs biodegradation and reduced Cu 2+ into Cu + for enhanced hydroxyl radical production, leading to a powerful inhibition effect on tumors (Liu et al., 2019)

The hurdle to dietary regulation being implemented as a medical intervention can be owed a large extent to our lack of understanding of molecular mechanisms and their concurrent effect on disease progression and outcome [126, 127]