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However, despite its synergistic effects with antibiotics in vitro , quercetins absorption and bioavailability in humans are relatively low, which may limit the practical application of its antimicrobial properties

An important aspect of this process is a significant reduction in both energy production and energy consumption

To further investigate the causal role of MPs/NPs in PD, upcoming studies should emphasize well-designed, large-scale prospective cohorts to assess individual exposure to plastic-related pollutants, elucidate the pathways of MPs/NPs into the central nervous system, establish safety thresholds for their neurotoxicity, explore the correlation between exposure levels and central nervous system accumulation, clarify the temporal relationship between MPs/NPs accumulation and PD pathology and symptom onset, and identify the neuropathological mechanisms triggered by relevant concentrations of MPs/NPs

The outcomes reveal that curcumin nanoparticles improved sperm, stereological parameters, and testosterone more than the group receiving only MPH

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