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Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling

Bhatt HD, McClain SA, Lee HM, Zimmerman T, Deng J, Johnson F, Gu Y, Golub LM

Trends Cell Biol

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The ingredients could act through two possible ways: (a) biological mechanism-oriented by exerting anti-photodamage actions, namely the products resulting of the direct and oxidative damage of DNA, downregulation the expression of MMPs, and pro-inflammatory cytokines confirmed in in vitro studies in keratinocytes and fibroblasts and in vivo and ex vivo studies, and/or (b) clinical effects-oriented by softening the visible effects of the skin sun damage, by providing moisturizing effect and refreshing properties, mainly corroborated by clinical trials