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Notably, treatment with broad-spectrum oral antibiotics partially diminished the protective efficacy of HABN against DSS-induced colitis, underscoring the role of microbiota in mediating these effects

[7]Current Patent Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY - KR101893879, 2018, B1 Location in patent: Paragraph 0287-0290

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For oral administration in mice, NR and NMN are first metabolized by the liver or GI tract into NAM, which can then be taken up by other tissues