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doi: 10.1124/jpet.119.259895 213 FeldmanJMChapmanB

Inhibition of histone deacetylase leads to the recruitment of transcription factor sp1 to the promoter region of G6PD (Makarona et al., 2014), which result in the increase in G6PD expression, suggesting that acetylation may be involved in the transcriptional regulation of G6PD

however, a reducing trend was observed

Taking up the extra volume means more water is displaced when the body is submerged so the buoyant force will be larger compared to the weight than it would be for a more dense body