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Mulberry leaves ameliorate obesity through enhancing brown adipose tissue activity and modulating gut microbiota

MdNPR1, a master regulator of SA signaling, interacts with and promotes the transactivation activity of MdTGA2.2, which binds to promoters and activates the transcription of genes involved in anthocyanin biosynthesis ( MdPAL , MdCHS , and MdDFR ) and regulation ( MdWRKY40 ), thereby positively regulating anthocyanin biosynthesis (Li et al., 2024)