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Recent studies demonstrate that prolonged supplementation, especially in combination with carbohydrates (CHO), may increase muscle total carnitine (TC) content in skeletal muscle [5,6,7]

For instance, the immunometabolism of T cells heavily relies on the continuous dynamic reshaping of mitochondria through fusion and fission events to maintain mitochondrial quality

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Furthermore, TMAO promotes diabetes by elevating fasting insulin, increasing insulin resistance (HOMA-IR), and inducing adipose tissue inflammation, contributing to glucose metabolism dysfunction and heightened cardiovascular event risks in diabetic patients (Subramaniam and Fletcher, 2018)