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This multivalency not only strengthens the binding affinity between PROTAC molecules and target proteins but also promotes efficient formation of ternary complexes (POI: PROTAC: E3 ligase), substantially enhancing degradation efficacy

This study explores a new source of immunogenic polypeptides originating from a nonconventional open reading frame within human insulin mRNA, which can be targeted by cytotoxic CD8 + T cells present in individuals with T1D, potentially contributing to -cell destruction in the disease