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Increased number of intracellular p-tau in the amygdala, subiculum, CA1 and CA3 of the hippocampus in AD male 3xTgAD mice models has been modified followed by taking a ketone ester diet comprising of D--hydroxybutyrate and (R)-1,3-butanediol (Kashiwaya et al., 2013)

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Research characterizes its modulation of the nitric oxide system and promotion of angiogenesis upregulating VEGF signaling and supporting endothelial function as a unifying mechanism linking its diverse tissue-repair effects 5

AA is transported into the brain and neurons primarily by the sodium-dependent vitamin C transporter 2 (SVCT2) 38