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Description

The molecular interactomes that underpin pressure-sensitive and insensitive aspects of POAG remain to be fully characterized with potential clues from recent genome-wide association study (GWAS) analyses of adult-onset POAG loci including genes that encode cholesterol-binding caveolin proteins CAV1/2, ABCA1 (ATP-binding cassette transporter 1), TGFBR3 (transforming growth factor beta receptor 3), FOXC1 (forkhead box C1), ELOVL5 (elongation of long chain fatty acids family member 5), ATOH7 (atonal homolog 7), CYP1B1 (a cytochrome P450 enzyme) and ATXN2 (ataxin isoform 2) proteins

Undas A, Pera-Kajn J, Gowacki R

Our results indicate that protein degradation pathways are instead used to cope with internalized aggregates and can be neuroprotective for some amount of time