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While eumelanin shows photoprotective capacity against ultraviolet (UV) [15], in contrast pheomelanin is weakly photoprotective and highly phototoxic, enhancing the UV-induced production of reactive oxygen species (ROS) and further damage of cells [16]

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In human studies, nitrate supplementation produces significant hemodynamic benefits, including lower systolic BP (SBP) and diastolic BP (DBP), improved endothelial function, and reduced arterial stiffness, with evidence of enhanced oxygen delivery/mitochondrial efficiency in muscle