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Nonetheless, NNMT has different roles in obesity, type 2 diabetes, and hepatic disease ( Due to heterogeneity, NNMT metabolic and epigenetic regulation vary between different cancers and specific TME regions

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MONARCH 1, a phase II study of abemaciclib, a CDK4 and CDK6 inhibitor, as a single agent, in patients with refractory HR(+)/HER2(-) metastatic breast cancer