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Geerts H, Spiros A, Roberts P, Carr R (2013) Quantitative systems Pharmacology as an extension of PK/PD modeling in CNS research and development

This can help treat anemia that occurs in CKD due to a B12 or folate deficiency

From an engineering standpoint, microbiome-responsive hydrogels, enzyme-cleavable coatings, and dual-acting nanosystems (e.g., combining photothermal therapy with antibiotic release) require significant refinement for clinical deployment

These contractile systems bind to receptors on bacterial cell surfaces, then inject a hollow tube into the cell wall, allowing ionic flux and depolarization of the inner membrane, thus killing the bacterial cell (Ge et al., 2015)