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The variations in ROS generation could affect the amounts of oxidized proteins, lipids, and DNA damage, increasing the colons vulnerability to GI disorders at these two intestinal sites (129)

Failing cardiomyocytes have reduced Ca 2+ levels in the sarcoplasmic reticulum (SR)

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Thus, this pathway operates at the interface of metabolism and communication, coupling oncogenic lipid synthesis with stromal remodeling and immune evasion, and establishing CHKA as both a functional biomarker and a promising therapeutic target in metabolically reprogrammed cancers