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This fundamental mechanism underpins its efficacy in repairing a wide array of tissues, from gut mucosa and muscle tendons to neural tissue

This functional role is mediated in part by the ability of CREB to serve as a downstream effector of CamKIV (Redmond et al., 2002) and CaM-dependent protein kinase kinase via components of the MAP kinase pathway and regulate the expression of Wnt2 (Wayman et al., 2006)