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In vitro , we validated this increased gene expression via RT-qPCR and observed that BDG increases the global intracellular concentration of glutathione as well as the level of the oxidized glutathione (GSSG) form

Am J Respir Cell Mol Biol37405413

This leads to mitochondrial metabolic disorders, affecting ATP production, activating kinases to produce O 2 - , triggering oxidative stress, and further damaging mitochondria [204]