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Translational deficitAdvanced delivery systems such as intranasal administration, nanoparticle encapsulation, and slow-release matrices remain under-validated for clinical use, limiting targeted bioavailability enhancements

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89,90 In addition to classical models in which CSCs arise from transformed tissue-resident stem cells, recent evidence suggests that differentiated tumor cells can reacquire stem-like properties under certain conditionsa phenomenon referred to as cellular plasticity

In fact, macrolides were also suggested as interesting adjunctive drugs to treat viral pneumonia including influenza and SARS-CoV-2

The World Health Organization (WHO) recommends that adults limit their total fat intake to 30% or less of their total energy intake