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Low, physiological levels of ROS are necessary for self-renew of stem cells while increased ROS levels activate proliferation, differentiation, senescence and apoptosis of stem cells in concentration-dependent manner [28]

10.1152/ajprenal.00089.2023 159 PadhiP.LouJ.JinH.AnantharamV.KanthasamyA.KanthasamyA

WM (n = 8)

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To prevent major seizures, valproate should not be discontinued abruptly, as this can precipitate status epilepticus with resulting maternal and fetal hypoxia and threat to life