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Several studies have reported that cell stimulation by a variety of growth factors, cytokines and G-protein-coupled receptors generates intracellular H2O2, e.g

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

USA 99 , 16041609 (2002)

Abeta and Tau regulate microglia metabolism via exosomes in Alzheimers disease

The mitochondria-targeted drug Met attenuates upregulation of the immune checkpoints programmed cell death protein 1 (PD-1) and lymphocyte activation gene-3 (LAG-3), thereby increasing CD8 + T cell infiltration and survival in the harsh tumor microenvironment (271)