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Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine

To aid in understanding the recommendations, background knowledge of the disease and established clinical procedures are provided in Notes

5.5 Hydrogel Hydrogel, a type of polymeric material, is extensively investigated in tissue engineering due to its exceptional biocompatibility, predictable degradation rate, appropriate elasticity, porous structure, and resemblance to the ECM (236, 237)