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The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise

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Although there is no formal recommendation for screening for vitamin B 12 deficiency in asymptomatic elderly people, the high prevalence, higher risk of deficiency in the elderly, easy and safe treatment availability warrant more liberal testing and vitamin supplementation in the elderly