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Modulating cyclic-nucleotide levels in the striatum may balance striatal dysfunction by inhibiting the indirect and activating the direct basal ganglia pathway, which potentially translates to both antidyskinetic and antiparkinsonian effects [140, 141]

This is a compounded formulation of Methylcobalamin, a form of vitamin B12, prepared in concentrations ranging from 1 mg/ml to 20 mg/ml

DOI: 10.1515/CCLM.2007.341 14

*Correspondence: Mulugeta Woldeselassie, [email protected] Present address: Mulugeta Woldeselassie, Addis Ababa University, College of Natural and Computational Sciences, Center for Food Science and Nutrition, Addis Ababa, Ethiopia Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, on day 30, group 1 indicated elevation in the activity of CAT (5.130.36 U/mg protein), whereas on day 30, the activity of CAT in group 2 further declined and was recorded as 4.910.55 U/mg protein