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By modulating the activity of DDR-related proteins, such as YTHDC1 [198], RAD18 [199], RRM1 [200] and HMGB1 [201], O-GlcNAcylation can regulate the DDR and affect genome stability, representing a potential therapeutic target for cancer therapy [202]

It is prescribed by the doctor for people who are suffering from weakness, fatigue, and nerve pain

We first investigated the effect of CAF-derived CM on the TGF1/SMAD2/3 pathway in A431 and SCC13 cells

To further elucidate the catalytic mechanism of how P300-mediated H3K18la, we performed molecular docking analysis using Autodock Vina to investigate the interaction between P300 and lactyl-CoA (PubChem: 1926-57-4), aiming to determine their binding mode and active sites (Fig