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While ferroptosis and gut dysbiosis have been extensively studied in isolation, growing evidence supports profound molecular crosstalk between these pathways, which synergistically drive OA progression

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124 In PAECs from Tie2Cre-mediated disruption of Egln1 mice, decreased PHD2 expression leads to HIF-2 upregulation and subsequent release of CXCL12

In the present article, the synthetic process of melanogenesis and associated core signaling pathways are summarized

A window period of 15 min from the scheduled time point was allowed for post dose recording of vital signs