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doi: 10.3390/antiox12040785 138 YangLDingWDongYChenCZengYJiangZet al

Acknowledgements The authors thank the Deanship of Scientific Research at KSU for funding this work through the research group Project No

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Key reports on ME/CFS have shown abnormal metabolites produced which demonstrate disturbed Amino Acid metabolism, dysregulated lipid metabolism with possible glycolysis impairment, possible Pyruvate Dehydrogenase (PDH) impairment, Urea Cycle dysregulation and overall TCA cycle substrates provision deficiency and reliance these cells for alternate fuel sources