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doi: 10.2147/jir.S432111 266 HuYWangYLiuSWangH

In vitro , they demonstrated TMAO's induction of the expression of inflammatory genes, including cyclooxygenase 2, interleukin 6, etc., both in human endothelial and smooth muscle cells, which eventually caused vascular endothelial inflammatory damage and enhanced the adhesion of leukocytes to vascular endothelia (46)